Arginine vasopressin – a mediator of chemotherapy induced emesis?

Neuropharmacology of chemotherapy-induced emesis.

Management of chemotherapy induced emesis

Important progress has been achieved in the last few years in the prevention of chemotherapy-induced nausea and vomiting thanks to the introduction in clinical practice first of the 5-HT3 antagonists and of the NK1 antagonists more recently. To prevent acute emesis induced by cisplatin/moderately emetogenic chemotherapy, a combination of aprepitant plus a 5-HT3 antagonist and dexamethasone/a 5-...

Effects of acupuncture on vasopressin-induced emesis in conscious dogs.

Although acupuncture has a significant clinical benefit, the mechanism of acupuncture remains unclear. Vasopressin, a posterior pituitary hormone, is involved in nausea and vomiting in humans and dogs. To investigate the antiemetic effects of acupuncture on vasopressin-induced emesis, gastroduodenal motor activity and the frequency of retching and vomiting were simultaneously recorded in consci...

Sleep protects against chemotherapy induced emesis.

BACKGROUND We present a clinical trial to assess the hypothesis that chemotherapy related emesis is reduced when drugs delivered while the patient is sleeping. METHODS Adults without previous sleep disturbances of vomit inducing conditions who were going to receive their first courses of 100 mg/m2 cisplatin were included. We reduced antiemetic prophylaxis consisting of ondansetron and dexamet...

Substance P is a major mediator causing delayed emesis in anthracycline-based chemotherapy--really?

We read with great interest the article written by Roila et al (2014) in which they indicated that in breast cancer patients treated with anthracycline plus cyclophosphamide chemotherapy and received the same antiemetic prophylaxis (aprepitant plus dexamethasone plus 5 HT3 antagonist) for acute emesis, aprepitant was not superior to dexamethasone. Dexamethasone had similar efficacy and toxicity...